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Showing 1–3 of 3 results
Advanced filters: Author: Uttam Tambar Clear advanced filters

  • The efficacy of the antibiotic trimethoprim, which inhibits bacterial dihydrofolate reductase (DHFR), is limited by the rapid emergence of resistant bacteria. Here, Manna et al. show that 4’-desmethyltrimethoprim inhibits DHFR and a common TMP-resistant variant, and impedes evolution of antibiotic resistance by selecting against the emergence of this variant.

    • Madhu Sudan Manna
    • Yusuf Talha Tamer
    • Erdal Toprak
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • A new small-molecule inhibitor that selectively binds an internal cavity in HIF-2α allosterically disrupts HIF-2α–ARNT interaction in vitro and in cells. This compound should allow scientists to interrogate HIF-2α's activity in hypoxia and cancer cells.

    • Thomas H Scheuermann
    • Qiming Li
    • Richard K Bruick
    Research
    Nature Chemical Biology
    Volume: 9, P: 271-276