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Showing 1–8 of 8 results
Advanced filters: Author: Uwe Klemm Clear advanced filters
  • Current optoacoustic probes for cancer imaging have limitations including background noise, long-term toxicity and scarce imaging depth in living tissue. Here the authors use Rhodobacter, purple bacteria rich in bacteriochlorophyll a, as an optoacoustic reporter to image tumor-associated macrophages in mice in vivo.

    • Lena Peters
    • Ina Weidenfeld
    • Andre C. Stiel
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-9
  • The ability to image macrophages in vivo would provide insights into homeostasis and disease but current imaging agents have effects on viability and functionality. Here the authors develop an optoacoustic probe based on a homogentisic acid-derived pigment related to melanin, capable of visualizing macrophage migration in mice.

    • Ina Weidenfeld
    • Christian Zakian
    • Andre C. Stiel
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12
  • Bacterial outer membrane vesicles (OMVs) are increasingly used as carriers for drug delivery. Here the authors encapsulate biopolymer melanin into OMVs, extending their use to optoacoustic imaging both in vitro and in vivo, and demonstrate the potential of this tool for photothermal therapy applications.

    • Vipul Gujrati
    • Jaya Prakash
    • Vasilis Ntziachristos
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10
  • Despite widespread transcription of LncRNA in mammalian systems, their contribution to metabolic homeostasis at the cellular and tissue level remains elusive. Here Pradas-Juni et al. describe a transcription factor–LncRNA pathway that couples hepatocyte nutrient sensing to regulation of glucose metabolism in mice.

    • Marta Pradas-Juni
    • Nils R. Hansmeier
    • Jan-Wilhelm Kornfeld
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-17
  • Chikungunya virus is a mosquito transmitted untreatable emergent pathogen that causes joint pain and fever. Here the authors perform a host genome-wide loss-of-function screen to identify targets for chikungunya antiviral drugs and validate hits using a mouse model of chikungunya infection.

    • Alexander Karlas
    • Stefano Berre
    • Marc Lecuit
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-14