Nature Search

Structural model of ATP-binding proteing associated with cystic fibrosis, multidrug resistance and bacterial transport

Stephen C. Hyde
Paul Emsley
Christopher F. Higgins
Research26 Jul 1990
Nature

Volume: 346, P: 362-365
Unconventional human CD61 pairing with CD103 promotes TCR signaling and antigen-specific T cell cytotoxicity

CD103⁺ T cells are associated with control over tumors but how this is mediated is unclear. Here the authors show that CD61 colocalizes and functionally combines with CD103 in the T cell synaptic response to promote antitumor T cell responses.

Megat H. B. A. Hamid
Pablo F. Cespedes
Tao Dong
ResearchOpen Access01 Apr 2024
Nature Immunology

Volume: 25, P: 834-846
Addendum: Precise tuning of gene expression levels in mammalian cells

Yale S. Michaels
Mike B. Barnkob
Tudor A. Fulga
Amendments and CorrectionsOpen Access10 Jun 2019
Nature Communications

Volume: 10, P: 1-3
Remodelling of the immune landscape by IFNγ counteracts IFNγ-dependent tumour escape in mouse tumour models

Losing sensitivity to IFNγ may contribute to tumor immune escape, but containment of IFNγ-insensitive tumors is also reported. Here the authors show, by analyzing immune landscape differences between WT and IFNγ receptor-deficient mouse B16-F10 melanoma tumors, that local IFNγ induces complex cellular crosstalk to promote anti-tumor immunity in the latter scenario.

Vivian W. C. Lau
Gracie J. Mead
Audrey Gérard
ResearchOpen Access02 Jan 2025
Nature Communications

Volume: 16, P: 1-19
Publisher Correction: Semaphorin 3A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8⁺ T cells

Mike B. Barnkob
Yale S. Michaels
Vincenzo Cerundolo
Amendments and CorrectionsOpen Access24 Apr 2024
Nature Communications

Volume: 15, P: 1
Semaphorin 3A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8⁺ T cells

Interactions between Semaphorin-3A (SEMA3A) and Neuropilin-1 (NRP1) and Plexin-A1 and Plexin-A4 have been shown to affect T cell development. Here the authors investigate how these interactions affect CD8⁺ T cells in tumour immunity, showing that NRP-1, Plexin-A1 and Plexin-A4 are upregulated on T cells allowing tumour derived SEMA3A to inhibit CD8⁺ T cell migration and function.

Mike B. Barnkob
Yale S. Michaels
Vincenzo Cerundolo
ResearchOpen Access12 Apr 2024
Nature Communications

Volume: 15, P: 1-18
Precise tuning of gene expression levels in mammalian cells

Analogue regulation of gene expression is important for normal function in mammals but existing genetic technologies are designed to achieve ON/OFF control. Here the authors develop synthetic microRNA silencing-mediated fine-tuners (miSFITs) to precisely control target gene expression levels.

Yale S. Michaels
Mike B. Barnkob
Tudor A. Fulga
ResearchOpen Access18 Feb 2019
Nature Communications

Volume: 10, P: 1-12
Dendritic cells enter lymph vessels by hyaluronan-mediated docking to the endothelial receptor LYVE-1

Jackson and colleagues show that dendritic cells transit to the lumen of lymphatic vessels through hyaluronan-mediated interactions with the endothelial receptor LYVE-1.

Louise A Johnson
Suneale Banerji
David G Jackson
Research15 May 2017
Nature Immunology

Volume: 18, P: 762-770
Impacts of combining anti-PD-L1 immunotherapy and radiotherapy on the tumour immune microenvironment in a murine prostate cancer model

Yiannis Philippou
Hanna T. Sjoberg
Richard J. Bryant
ResearchOpen Access09 Jul 2020
British Journal of Cancer

Volume: 123, P: 1089-1100

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