Eukaryotic cells store neutral lipids in cytoplasmic lipid droplets. Processes regulating the formation of these organelles are at present unknown. A genome-wide RNAi screen in Drosophila cells identifies genes involved in lipid droplet formation and utilization, finding that 1% of all genes are involved in these processes. This study will lead to an understanding of human diseases involving excessive lipid storage.
- Yi Guo
- Tobias C. Walther
- Robert V. Farese
