LEDGF/p75, a protein involved in HIV integration and leukaemia, interacts with various cellular proteins via its integrase binding domain (IBD). Here, the authors show that the interaction is mediated by an intrinsically disordered IBD-binding motif (IBM) on all known cellular partners of LEDGF/p75.
- Petr Tesina
- Kateřina Čermáková
- Pavlína Řezáčová