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Cross-platform motif discovery and benchmarking to explore binding specificities of poorly studied human transcription factors

Cross-platform benchmarking of DNA binding specificity models highlights top-performing motif discovery methods and demonstrates the potential of advanced models to capture alternative binding modes of human transcription factors.

Ilya E. Vorontsov
Ivan Kozin
Ivan V. Kulakovskiy
ResearchOpen Access07 Nov 2025
Communications Biology

Volume: 8, P: 1-19
Delaminated zeolite precursors as selective acidic catalysts

A. Corma
V. Fornes
J. G. Buglass
Research26 Nov 1998
Nature

Volume: 396, P: 353-356
Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network

Mammalian genomes are scattered with repetitive sequences, but their biology remains largely elusive. Here, the authors show that transcription can initiate from short tandem repetitive sequences, and that genetic variants linked to human diseases are preferentially found at repeats with high transcription initiation level.

Mathys Grapotte
Manu Saraswat
Charles-Henri Lecellier
ResearchOpen Access02 Jun 2021
Nature Communications

Volume: 12, P: 1-18
Mechanical Properties of Alkali Treated Casein Films

N Somanathan
M D Naresh
R Sanjeevi
Research01 Jul 1992
Polymer Journal

Volume: 24, P: 603-611
Exploring the impact of lipid stress on sperm cytoskeleton: insights and prospects

High-fat diets disrupt testicular function by accumulating lipids, impairing sperm production and affecting the cytoskeleton of spermatogenic cells. This Perspective aims to understand these mechanisms to develop treatments for infertility in men with obesity.

Tania E. Saez Lancellotti
María V. Avena
Miguel W. Fornes
Reviews11 Nov 2024
Nature Reviews Urology

Volume: 22, P: 294-312
Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database

Community microattribution review of the evidence for colon cancer risk conferred by constitutional variants in MLH1, MSH2, MSH6 and PMS2 has resulted in the reclassification of two-thirds of the variants reported in existing databases and led to clinical recommendations for the interpretation of 1,370 variants that do not result in obvious protein truncation.

Bryony A Thompson
Amanda B Spurdle
Victor-Manuel Barbera
Research22 Dec 2013
Nature Genetics

Volume: 46, P: 107-115
PARP-2 sustains erythropoiesis in mice by limiting replicative stress in erythroid progenitors

J Farrés
L Llacuna
J Yélamos
Research12 Dec 2014
Cell Death & Differentiation

Volume: 22, P: 1144-1157

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Cross-platform motif discovery and benchmarking to explore binding specificities of poorly studied human transcription factors

Delaminated zeolite precursors as selective acidic catalysts

Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network

Mechanical Properties of Alkali Treated Casein Films

Exploring the impact of lipid stress on sperm cytoskeleton: insights and prospects

Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database

PARP-2 sustains erythropoiesis in mice by limiting replicative stress in erythroid progenitors

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