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A primary cilia–autophagy axis in hippocampal neurons is essential to maintain cognitive resilience

Exploring the molecular mechanisms by which the blood-borne factor osteocalcin promotes cognitive resilience, Rivagorda, Romeo-Guitart et al. identify a primary cilia axis through which osteocalcin promotes autophagy in neurons.

Manon Rivagorda
David Romeo-Guitart
Franck Oury
ResearchOpen Access21 Feb 2025
Nature Aging

Volume: 5, P: 450-467
Slc20a1 and Slc20a2 regulate neuronal plasticity and cognition independently of their phosphate transport ability

Mariana Ramos-Brossier
David Romeo-Guitart
Franck Oury
ResearchOpen Access09 Jan 2024
Cell Death & Disease

Volume: 15, P: 1-18
Primary-cilium-dependent autophagy controls epithelial cell volume in response to fluid flow

Orhon et al. report that primary-cilium-mediated fluid flow sensing triggers autophagy through LKB1–AMPK–mTOR signalling, and thereby controls the volume of kidney epithelial cells.

Idil Orhon
Nicolas Dupont
Patrice Codogno
Research23 May 2016
Nature Cell Biology

Volume: 18, P: 657-667
Novel function of PiT1/SLC20A1 in LPS-related inflammation and wound healing

Eugénie Koumakis
Joëlle Millet-Botti
Anne Forand
ResearchOpen Access12 Feb 2019
Scientific Reports

Volume: 9, P: 1-15