Nature Search

Multi-ancestry genome-wide association study of kidney cancer identifies 63 susceptibility regions

A multi-ancestry genome-wide association meta-analysis of kidney cancer identifies 63 regions associated with disease susceptibility including one locus that was associated with increased risk in individuals with African ancestry.

Mark P. Purdue
Diptavo Dutta
Stephen J. Chanock
Research26 Apr 2024
Nature Genetics

Volume: 56, P: 809-818
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Exome-wide analysis identifies rare and low-frequency coding variants associated with body mass index. Gene-based meta-analysis and functional studies implicate 13 genes, eight of which are novel, and neuronal pathways as factors in human obesity.

Valérie Turcot
Yingchang Lu
Ruth J. F. Loos
Research22 Dec 2017
Nature Genetics

Volume: 50, P: 26-41
Hypertensive eye disease

Hypertensive eye disease (HED) refers to dieases of the eye that are associated with acute or chronic elevations in blood pressure. This Primer discusses the epidemiology, mechanisms, diagnosis and treatment of HED.

Carol Y. Cheung
Valérie Biousse
Tien Y. Wong
Reviews10 Mar 2022
Nature Reviews Disease Primers

Volume: 8, P: 1-18
Author Correction: Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

Philippe Bégin
Jeannie Callum
Donald M. Arnold
Amendments and CorrectionsOpen Access12 Jan 2022
Nature Medicine

Volume: 28, P: 212
Genome-wide association study identifies multiple new loci associated with Ewing sarcoma susceptibility

Ewing sarcoma (EWS) is a rare pediatric bone cancer typically involving the EWSR1-FLI1 fusion. Here the authors perform a genome-wide association study and report three new EWS risk loci that reside near GGAA repeat sequences, and identify candidate genes (RREB1 and KIZ) from eQTL analysis.

Mitchell J. Machiela
Thomas G. P. Grünewald
Olivier Delattre
ResearchOpen Access09 Aug 2018
Nature Communications

Volume: 9, P: 1-8
Rare and low-frequency coding variants alter human adult height

Data from over 700,000 individuals reveal the identity of 83 sequence variants that affect human height, implicating new candidate genes and pathways as being involved in growth.

Eirini Marouli
Mariaelisa Graff
Guillaume Lettre
Research01 Feb 2017
Nature

Volume: 542, P: 186-190
Mutations in CFAP43 and CFAP44 cause male infertility and flagellum defects in Trypanosoma and human

Asthenozoospermia is a major cause of male infertility, and multiple morphological abnormalities of the flagella (MMAF) is a particularly severe form. Here, using whole-exome sequencing of 78 MMAF patients, the authors identify mutations in two WDR proteins, CFAP43 and CFAP44, and confirm that these proteins are required for flagellogenesis in mouse and Trypanosoma brucei.

Charles Coutton
Alexandra S. Vargas
Pierre F. Ray
ResearchOpen Access15 Feb 2018
Nature Communications

Volume: 9, P: 1-18
Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

A randomized trial in patients hospitalized with COVID-19 showed no benefit and potentially increased harm associated with the use of convalescent plasma, with subgroup analyses suggesting that the antibody profile in donor plasma is critical in determining clinical outcomes.

Philippe Bégin
Jeannie Callum
Donald M. Arnold
ResearchOpen Access09 Sept 2021
Nature Medicine

Volume: 27, P: 2012-2024
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Valérie Turcot
Yingchang Lu
Ruth J. F. Loos
Amendments and Corrections16 Mar 2018
Nature Genetics

Volume: 50, P: 766-767
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Valérie Turcot
Yingchang Lu
Ruth J. F. Loos
Amendments and Corrections16 Mar 2018
Nature Genetics

Volume: 50, P: 765-766
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Valérie Turcot
Yingchang Lu
Ruth J. F. Loos
Amendments and Corrections03 Jun 2019
Nature Genetics

Volume: 51, P: 1191-1192
Reply to: Concerns about estimating relative risk of death associated with convalescent plasma for COVID-19

Philippe Bégin
Jeannie Callum
Donald M. Arnold
Research10 Jan 2022
Nature Medicine

Volume: 28, P: 53-58
Microscopic charcoals in ocean sediments off Africa track past fire intensity from the continent

Large grassland and open savannah fires occurred during humid periods of the Holocene in subtropical Africa and contributed to increased carbon dioxide in the atmosphere, according to the concentration and morphotype of microcharcoals in marine sediments off Africa

Aritina Haliuc
Anne-Laure Daniau
Xavier Crosta
ResearchOpen Access22 Apr 2023
Communications Earth & Environment

Volume: 4, P: 1-11
36-month durability of ultrasound renal denervation for hypertension resistant to combination therapy in RADIANCE-HTN TRIO

Michael J. Bloch
Ajay J. Kirtane
Patric Kröpil
ResearchOpen Access27 Sept 2024
Hypertension Research

Volume: 47, P: 3467-3472
Probiotic from human breast milk, Lactobacillus fermentum, promotes growth in animal model of chronic malnutrition

Pierre Poinsot
Armelle Penhoat
Noël Peretti
Research05 Feb 2020
Pediatric Research

Volume: 88, P: 374-381

Search

Multi-ancestry genome-wide association study of kidney cancer identifies 63 susceptibility regions

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Hypertensive eye disease

Author Correction: Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

Genome-wide association study identifies multiple new loci associated with Ewing sarcoma susceptibility

Rare and low-frequency coding variants alter human adult height

Mutations in CFAP43 and CFAP44 cause male infertility and flagellum defects in Trypanosoma and human

Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Reply to: Concerns about estimating relative risk of death associated with convalescent plasma for COVID-19

Microscopic charcoals in ocean sediments off Africa track past fire intensity from the continent

36-month durability of ultrasound renal denervation for hypertension resistant to combination therapy in RADIANCE-HTN TRIO

Probiotic from human breast milk, Lactobacillus fermentum, promotes growth in animal model of chronic malnutrition

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