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Showing 1–5 of 5 results
Advanced filters: Author: Valdone Maciulyte Clear advanced filters

  • In areas such as animal research and agriculture a single sex is often required in abundance, leading to wasted resources and ethical considerations. Here the authors develop a CRISPR/Cas9 mediated synthetic lethal system that enables the production of single sex offspring that can be repurposed for use in multiple organisms.

    • Charlotte Douglas
    • Valdone Maciulyte
    • James M. A. Turner
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • If left unrepaired, meiotic DSBs are toxic to mammalian cells, thus oocytes in which DSBs persist are eliminated by the DNA-damage checkpoint. Here the authors provide insights into the roles of PUMA, NOXA and BAX during DNA damage checkpoint that eliminates Dmc1−/− and Msh5−/− oocytes.

    • Elias ElInati
    • Agata P. Zielinska
    • James M. A. Turner
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • ATR kinase is required for meiosis in non-mammalian model organisms. Here the authors demonstrate, using a tissue-specific knockout approach, that ATR is also essential for male meiosis in mouse, regulating meiotic recombination and synapsis.

    • Alexander Widger
    • Shantha K. Mahadevaiah
    • James M.A. Turner
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12