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Showing 1–2 of 2 results
Advanced filters: Author: Valentina Andrioletti Clear advanced filters

  • Deregulation of transcription by oncogenes leads to collisions of RNA Polymerase II (RNAPII) with DNA replication machinery (transcription-replication conflicts, TRCs). This study shows that RNAPII activates ATM kinase at TRCs providing a mechanism for replication fork stalling and ATM activation at TRCs.

    • Elias Einig
    • Chao Jin
    • Nikita Popov
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17