Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–8 of 8 results
Advanced filters: Author: Valentina Cecatiello Clear advanced filters

  • The Drosophila tumour necrosis factor (TNF) system comprises a single ligand Eiger (Egr) and two receptors. The structure of Egr in complex with the extracellular domain of the receptor Grindelwald and accompanying data suggest that distinct affinities of TNF ligand for its receptors mediate non-redundant functions.

    • Valentina Palmerini
    • Silvia Monzani
    • Marina Mapelli
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Although the asymmetric dimethylation of histone H3R2 acts as a repressive mark, new studies reveal that symmetrically dimethylated H3R2 (H3R2me2s) is a functional histone mark in vivo. The RBBP7 co-repressor is excluded from binding H3R2me2s in favor of the coactivator WDR5, which poises euchromatic genes for transcription activation upon cell-cycle exit and differentiation.

    • Valentina Migliori
    • Julius Müller
    • Ernesto Guccione
    Research
    Nature Structural & Molecular Biology
    Volume: 19, P: 136-144

  • LGN and NuMA link epithelial polarity sites with astral microtubules and associate with dynein, but the architecture of such cortical force-generating complexes is unknown. Here, the authors report the crystal structure of NuMA:LGN hetero-hexamers, and unveil their role in promoting the assembly of active cortical dynein/dynactin motors.

    • Laura Pirovano
    • Simone Culurgioni
    • Marina Mapelli
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • HECT E3 ligases directly catalyze ubiquitin transfer to their substrates. The crystal structure of ubiquitin-loaded Nedd4 HECT domain in complex with ubiquitin is now presented, revealing insights into the mechanisms for catalytic priming and sequential addition and suggesting the basis for Lys63 specificity.

    • Elena Maspero
    • Eleonora Valentini
    • Simona Polo
    Research
    Nature Structural & Molecular Biology
    Volume: 20, P: 696-701

  • NEDD4 is a key E3 ubiquitin ligase involved in development and cancer, however, specific inhibitors against NEDD4 remain underdeveloped. Here, the authors identify the inhibitory mechanism of norclomipramine and develop covalent inhibitors targeting NEDD4’s non-catalytic cysteine C627, with one compound showing potent inhibition and promising pharmacokinetics, advancing therapeutic strategies against NEDD4-related diseases.

    • Elena Maspero
    • Anna Cappa
    • Simona Polo
    ResearchOpen Access
    Communications Chemistry
    Volume: 8, P: 1-13

  • A native-SAD (single-wavelength anomalous diffraction) data collection strategy enables phasing using anomalous signal from a single native crystal, facilitating straightforward macromolecular X-ray structure determination.

    • Tobias Weinert
    • Vincent Olieric
    • Meitian Wang
    Research
    Nature Methods
    Volume: 12, P: 131-133