Winski et al. evaluate the miRNA abundance in plasma of around 200 patients with abdominal aortic aneurysm (AAA) and matched controls. MiR-15a is identified as a candidate biomarker and AAA mouse models and additional patient samples are used to determine miR-15a’s localization, expression, and the impact of miR-15a dysregulation.
- Greg Winski
- Ekaterina Chernogubova
- Lars Maegdefessel