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Showing 1–8 of 8 results
Advanced filters: Author: Valentina Snetkova Clear advanced filters

  • The authors summarize the data produced by phase III of the Encyclopedia of DNA Elements (ENCODE) project, a resource for better understanding of the human and mouse genomes.

    • Federico Abascal
    • Reyes Acosta
    • Zhiping Weng
    ResearchOpen Access
    Nature
    Volume: 583, P: 699-710

  • Cas12a represents the next generation of gene editing. Here, the authors present the generation and validation of a Cas12a transgenic mouse model. Additionally, the authors create whole-genome Cas12a knockout libraries, and demonstrate their utility across multiple in vitro and in vivo screens.

    • Wei Jin
    • Yexuan Deng
    • Marco J. Herold
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Mutagenesis of 23 ultraconserved enhancers and examination of their activities in transgenic mouse reporter assays show that overall their regulatory properties are robust to mutation. Manipulation of endogenous loci in mice corroborates reporter assay data.

    • Valentina Snetkova
    • Athena R. Ypsilanti
    • Diane E. Dickel
    Research
    Nature Genetics
    Volume: 53, P: 521-528

  • In this Review, the authors discuss explanations for why ultraconserved sequences — which are presumed to be functionally crucial on the basis of strong evolutionary constraint — often result in surprisingly minor phenotypic consequences when experimentally disrupted. They also discuss the wider implications of extreme non-coding conservation for understanding the mechanisms of gene regulation and human variant interpretation.

    • Valentina Snetkova
    • Len A. Pennacchio
    • Diane E. Dickel
    Reviews
    Nature Reviews Genetics
    Volume: 23, P: 182-194

  • The authors summarize the history of the ENCODE Project, the achievements of ENCODE 1 and ENCODE 2, and how the new data generated and analysed in ENCODE 3 complement the previous phases.

    • Federico Abascal
    • Reyes Acosta
    • Richard M. Myers
    Reviews
    Nature
    Volume: 583, P: 693-698