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Showing 1–3 of 3 results
Advanced filters: Author: Valeria Calvaresi Clear advanced filters

  • Chagas disease, caused by Trypanosoma cruzi, lacks an effective vaccine. Here, the authors report the cryo-EM structure of TcPOP, a potential vaccine antigen, in open and closed states and validate its immunogenic potential for invasion-blocking antibodies.

    • Sagar Batra
    • Francisco Olmo
    • Ivan Campeotto
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • In this paper, the authors use hydrogen-deuterium exchange mass spectrometry to describe how the SARS-CoV-2 spike glycoprotein has evolved its structural dynamics features and receptor binding capability from the emergence of the original Wuhan isolate to the recent omicron variant. The findings reported shed light on the evolution of SARS-CoV-2 in the human population and the mechanisms of emergence of new variants.

    • Valeria Calvaresi
    • Antoni G. Wrobel
    • Argyris Politis
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • Calvaresi et al. use hydrogen-deuterium exchange coupled to mass spectrometry to compare the conformational dynamics of the human heat shock protein Hsp70 when free and when associated with liposomes composed of common lysosomal lipids. They also investigate the conformational changes occuring in Hsp70 when transitioning from the pH of the cytosol to that of early and late lysosomes. This study provides new molecular insights into how Hsp70 can stabilize endo-lysosomal membranes and inhibit the uncontrolled release of degradative enzymes linked to lysosomal storage disorders.

    • Valeria Calvaresi
    • Line T. Truelsen
    • Kasper D. Rand
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-11