Nature Search

Autosomal-recessive SASH1 variants associated with a new genodermatosis with pigmentation defects, palmoplantar keratoderma and skin carcinoma

Jean- Benoît Courcet
Siham Chafai Elalaoui
Laurence Faivre
Research15 Oct 2014
European Journal of Human Genetics

Volume: 23, P: 957-962
FANCD2 modulates the mitochondrial stress response to prevent common fragile site instability

Fernandes et al. discover a connection between the mitochondrial stress response and genomic stability. They find that transcription of common fragile site (CFS) genes is induced by mitochondrial stress, whereas a regulator of CFS stability, FANCD2, acts to dampen the mitochondrial stress response and transcription-associated replication stress. These findings suggest a FANCD2-mediated coordination of nuclear and mitochondrial responses to stress.

Philippe Fernandes
Benoit Miotto
Valeria Naim
ResearchOpen Access29 Jan 2021
Communications Biology

Volume: 4, P: 1-16
ERCC1 and MUS81–EME1 promote sister chromatid separation by processing late replication intermediates at common fragile sites during mitosis

Breakage and rearrangement of common fragile sites (CFSs) can cause genomic instability. Rosselli and colleagues demonstrate that the endonuclease subunit ERCC1 and the endonuclease MUS18–EME1 are recruited to FANCD2-binding CFSs in mitosis to mediate their processing.

Valeria Naim
Therese Wilhelm
Filippo Rosselli
Research30 Jun 2013
Nature Cell Biology

Volume: 15, P: 1008-1015
The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities

The FANC and the BLM pathways collaborate during mitosis to prevent micronucleation and chromosome abnormalities.

Valeria Naim
Filippo Rosselli
Research24 May 2009
Nature Cell Biology

Volume: 11, P: 761-768
FANCD2 promotes mitotic rescue from transcription-mediated replication stress in SETX-deficient cancer cells

A synthetic lethal interaction is reported between the R-loop helicase Senataxin (SETX) and Fanconi anemia pathway proteins, with SETX deficiency increasing replication stress-induced chromosome fragility & activation of mitotic DNA synthesis.

Maha Said
Viviana Barra
Valeria Naim
ResearchOpen Access21 Dec 2022
Communications Biology

Volume: 5, P: 1-13
Understanding DNA replication and replication stress as avenues to combat cancer

The Collection “DNA Replication and Replication Stress” brings together original research articles, critical reviews, and perspectives from scientists with diverse viewpoints and areas of expertise in DNA replication, genome integrity, and cancer.

Valeria Naim
EditorialOpen Access27 Nov 2024
Communications Biology

Volume: 7, P: 1-2
Mitochondrial DNA is a target of HBV integration

Hepatitis B virus (HBV) integration events are profiled in liver tissues from hepatocellular carcinoma patients using a high-throughput HBV integration sequencing method and bioinformatics. HBV is often found to integrate in mitochondrial DNA.

Domenico Giosa
Daniele Lombardo
Teresa Pollicino
ResearchOpen Access03 Jul 2023
Communications Biology

Volume: 6, P: 1-14

Search

Filter By:

Autosomal-recessive SASH1 variants associated with a new genodermatosis with pigmentation defects, palmoplantar keratoderma and skin carcinoma

FANCD2 modulates the mitochondrial stress response to prevent common fragile site instability

ERCC1 and MUS81–EME1 promote sister chromatid separation by processing late replication intermediates at common fragile sites during mitosis

The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities

FANCD2 promotes mitotic rescue from transcription-mediated replication stress in SETX-deficient cancer cells

Understanding DNA replication and replication stress as avenues to combat cancer

Mitochondrial DNA is a target of HBV integration

Search

Quick links