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Advanced filters: Author: Valerie H. Odegard Clear advanced filters

  • Somatic hypermutation (SHM) introduces mutations in the variable region of immunoglobulin genes, to generate high-affinity B-cell antigen receptors. But, as discussed in this Review, how SHM is targeted to immunoglobulin genes is a subject of intense research and debate.

    • Valerie H. Odegard
    • David G. Schatz
    Reviews
    Nature Reviews Immunology
    Volume: 6, P: 573-583