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Showing 1–5 of 5 results
Advanced filters: Author: Valery V. Pak Clear advanced filters

  • Hydrogen peroxide is a signaling molecule that can also cause damage if its levels are too high. Here, the authors report HyPerFLEX, a fluorescent sensor with tenable colors, to track very low peroxide levels in cellular organelles, even in low-oxygen or highly oxidizing environments.

    • Ekaterina S. Potekhina
    • Dina I. Bass
    • Vsevolod V. Belousov
    Research
    Nature Chemical Biology
    P: 1-12

  • Amino acids modulate insulin secretion via amino acid transporters expressed on β cells. Here, the authors show a VGF-derived peptide NERP-4 acts as a positive allosteric modulator on the amino acid transporter SNAT2/SLC38A2, thereby contributing to β-cell maintenance and function.

    • Weidong Zhang
    • Ayako Miura
    • Masamitsu Nakazato
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-21

  • Hypercholesterolemia is associated with lipid peroxidation induced reactive dicarbonyl adducts. Here the authors show that the dicarbonyl scavenger, 2-hydroxybenzylamine(2-HOBA), decreases reactive dicarbonyl modifications of LDL and HDL, improves HDL function, reduces atherosclerosis and promotes features of stable plaques in a mouse model of hypercholestrolemia.

    • Huan Tao
    • Jiansheng Huang
    • MacRae F. Linton
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • Reference assemblies of great ape sex chromosomes show that Y chromosomes are more variable in size and sequence than X chromosomes and provide a resource for studies on human evolution and conservation genetics of non-human apes.

    • Kateryna D. Makova
    • Brandon D. Pickett
    • Adam M. Phillippy
    ResearchOpen Access
    Nature
    Volume: 630, P: 401-411