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Showing 1–3 of 3 results
Advanced filters: Author: Valur Olafsson Clear advanced filters

  • How the human dopamine system changes during adolescence is still unclear. Here, the authors combine PET and quantitative MRI measures to show that dopamine D2/D3 receptor availability decreases with age while presynaptic dopamine vesicular storage was developmentally stable by age 18

    • Bart Larsen
    • Valur Olafsson
    • Beatriz Luna
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • Uterine leiomyomas are common benign tumors. Here, a meta-analysis of two European leiomyoma GWAS uncovers 21 leiomyoma risk variants at 16 loci, providing evidence of genetic overlap between leiomyoma and various benign and malignant tumors and highlighting the role of estrogen in tumor growth.

    • Thorunn Rafnar
    • Bjarni Gunnarsson
    • Kari Stefansson
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-9

  • Thorhildur Olafsdottir et al. report a genome-wide association study of pelvic organ prolapse (POP) in a total of 15,010 cases and 340,734 controls from Iceland and the UK. They identify 8 sequence variants at 7 loci associated with POP that highlight the role of connective tissue metabolism and estrogen in POP.

    • Thorhildur Olafsdottir
    • Gudmar Thorleifsson
    • Kari Stefansson
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-10