Herpesviruses are shown to specifically block innate antiviral responses by inducing the aggregation of key signalling molecules nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) essential modulator (NEMO) and receptor-interacting protein kinase 1 (RIPK1) and their degradation by selective autophagy, thereby blocking the activation of NF-κB and the induction of necroptosis, respectively.
- Elena Muscolino
- Rebekka Schmitz
- Wolfram Brune
