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Showing 1–2 of 2 results
Advanced filters: Author: Vanesa Vinciauskaite Clear advanced filters

  • Inhibitors of the protein kinase Wee1 are promising drugs for cancer therapy. Here, the authors show that these drugs activate the integrated stress response via GCN2, synergising with mRNA translation defects. They suggest strategies such as PROTACs or ISR inhibitors to improve WEE1 mediated toxicity.

    • Jordan C. J. Wilson
    • JiaYi Zhu
    • Stephen P. Jackson
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • A new specific, small-molecule activator of the PI3Kα isoform (UCL-TRO-1938) identified through high-throughput screening can transiently activate PI3K signalling and biological responses in cells and tissues, with potential therapeutic applications in tissue protection and regeneration.

    • Grace Q. Gong
    • Benoit Bilanges
    • Bart Vanhaesebroeck
    Research
    Nature
    Volume: 618, P: 159-168