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Nature Cell Biology (1)
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MAPL regulates gasdermin-mediated release of mtDNA from lysosomes to drive pyroptotic cell death

Nguyen, Collier et al. find a mitochondria–lysosome inflammatory pathway regulated by the SUMO E3 ligase MAPL, which promotes vesicular mtDNA transport to lysosomes and subsequent gasdermin-dependent lysosomal permeabilization to activate pyroptosis.

Mai Nguyen
Jack J. Collier
Heidi M. McBride
ResearchOpen Access13 Oct 2025
Nature Cell Biology

P: 1-17
The dynamic interacting landscape of MAPL reveals essential functions for SUMOylation in innate immunity

Karine Doiron
Vanessa Goyon
Heidi M. McBride
ResearchOpen Access07 Mar 2017
Scientific Reports

Volume: 7, P: 1-11

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MAPL regulates gasdermin-mediated release of mtDNA from lysosomes to drive pyroptotic cell death

The dynamic interacting landscape of MAPL reveals essential functions for SUMOylation in innate immunity

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