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Showing 1–4 of 4 results
Advanced filters: Author: Varun Sahu Clear advanced filters

  • Co-dependency mapping assays have revealed genetic dependencies in cancer and could shed light on chromatin crosstalk mechanisms. Here, the authors establish a pipeline to integrate co-dependency mapping screens with molecular information in pan-cancer cell lines in order to reveal chromatin complexes and potential drug targets.

    • Xiao Chen
    • Yinglu Li
    • Chao Lu
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • Spy is an ATP independent chaperone that can act as both a holdase and a foldase towards topologically simple substrates. Assessing the interaction of Spy and apoflavodoxin, a complex client, the authors show that Spy’s activity is substrate specific. Spy binds partially unfolded states of apoflavodoxin tightly, which limits the possibility of folding and converts Spy to a pure holdase.

    • Rishav Mitra
    • Varun V. Gadkari
    • James C. A. Bardwell
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • Notch receptors can exert different roles in cancer. In this manuscript, the authors reveal that Notch1 activation and EMT promote tumor initiation and cancer cell heterogeneity in squamous cell carcinoma, while the repression of Notch3 by ZEB1 limits Notch1-induced differentiation, permitting Notch1-mediated EMT.

    • Mitsuteru Natsuizaka
    • Kelly A. Whelan
    • Hiroshi Nakagawa
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16

  • Biodiversity conservation is critical for promoting ecosystem services and human well-being, but current conservation efforts fail to protect most high priority zones. A mix of land-sparing and land-sharing is needed to safeguard critical ecosystems in India and across the Global South.

    • Arjun Srivathsa
    • Divya Vasudev
    • Uma Ramakrishnan
    Research
    Nature Sustainability
    Volume: 6, P: 568-577