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Advanced filters: Author: Vasiliki Triantafyllia Clear advanced filters

Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison

Andreakos and colleagues provide a longitudinal study comparing patients with COVID-19 to patients infected with influenza. They report a dysregulated interferon response whereby IFN-λ and type I IFN production were diminished and delayed in patients with COVID-19, exhibiting a response that is ‘untuned’ with other inflammatory cytokines.

Ioanna-Evdokia Galani
Nikoletta Rovina
Evangelos Andreakos
Research04 Dec 2020
Nature Immunology

Volume: 22, P: 32-40
Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestries

Genetic and functional studies implicate allele-specific regulation of OAS1 splicing and nonsense-mediated decay in COVID-19 severity. The OAS1 risk haplotype is also associated with reduced SARS-CoV-2 clearance in a clinical trial with pegIFN-λ1.

A. Rouf Banday
Megan L. Stanifer
Ludmila Prokunina-Olsson
ResearchOpen Access14 Jul 2022
Nature Genetics

Volume: 54, P: 1103-1116
Severity of neonatal influenza infection is driven by type I interferon and oxidative stress

Ogan K. Kumova
Ioanna-Evdokia Galani
Alison J. Carey
Research09 Nov 2022
Mucosal Immunology

Volume: 15, P: 1309-1320

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