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Showing 1–3 of 3 results
Advanced filters: Author: Vasilios Tsarouhas Clear advanced filters
  • Polarity-deficient epithelial cells are eliminated through Sas-Ptp10D-mediated suppression of EGFR signalling during cell competition. Here the authors show the constitutively active, phosphomimetic WASH can activate both EGFR and Hippo signalling and thereby, induces the overgrowth of these polarity-deficient cells in Drosophila and in proliferating epithelial cells, WASH activation differentially affects the separate recycling routes of EGFR and its inhibitor Ptp10D.

    • Dan Liu
    • Vasilios Tsarouhas
    • Christos Samakovlis
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12
  • The regulation and coordination of F-actin networks are not well understood. Here, the authors show an antagonistic relationship between endosomal F-actin assembly and cortical bundle integrity during epithelial tube maturation that is regulated by kinase and phosphatase activity modifying WASH.

    • Vasilios Tsarouhas
    • Dan Liu
    • Christos Samakovlis
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16
  • The wound-healing transcription factor Grainy head upregulates a receptor tyrosine kinase of the Ret-family, Stitcher. Stitcher orchestrates re-epithelialization by triggering rearrangements of the actin cytoskeleton and changes in gene expression through Erk phosphorylation and regulation of Grainy head activity.

    • Shenqiu Wang
    • Vasilios Tsarouhas
    • Christos Samakovlis
    Research
    Nature Cell Biology
    Volume: 11, P: 890-895