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Showing 1–3 of 3 results
Advanced filters: Author: Vasumathi Kameswaran Clear advanced filters

  • The underlying mechanism of acquired resistance to targeted therapy in cancer remains to be explored. Here, the authors show that upregulation of the FOSL1 transcription factor restores YAP/TEAD occupancy on chromatin to drive resistance to GNE-7883, an allosteric TEAD inhibitor.

    • Sayantanee Paul
    • Thijs J. Hagenbeek
    • Anwesha Dey
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-21

  • The boundaries of topologically associating domains (TADs) arise from the ability of the CTCF protein to stop extrusion of chromatin loops by cohesin. Here the authors find that CTCF positions cohesin through its N-terminus but does not control its overall binding dynamics on chromatin, and show how the orientation of CTCF binding sites translates into genome folding patterns.

    • Elphège P. Nora
    • Laura Caccianini
    • Benoit G. Bruneau
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13