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Advanced filters: Author: Vatsala Sagar Clear advanced filters

  • Rio2 is an atypical protein kinase required for pre-40S subunit maturation. The crystal structure of eukaryotic Rio2 with bound ATP and Mg2+ reveals an unusual phosphoaspartate intermediate typically observed in P-type ATPases. Rio2 has in vitro ATPase activity, and its catalytic activity stimulates its own dissociation from the ribosome, which is required for pre-40S maturation.

    • Sébastien Ferreira-Cerca
    • Vatsala Sagar
    • Nicole LaRonde-LeBlanc
    Research
    Nature Structural & Molecular Biology
    Volume: 19, P: 1316-1323