The immunosuppressive activity of T regulatory (Treg) cells has been shown to impair antitumor responses, but depleting these cells has not proved highly promising in the clinic. Wayne Hancock and his colleagues now report that targeting the histone acetyltransferase p300 in Treg cells is an alternate approach to modulating the function of Treg cells and show that inhibiting p300 impairs tumor growth without promoting autoimmunity.
- Yujie Liu
- Liqing Wang
- Wayne W Hancock
