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Showing 1–3 of 3 results
Advanced filters: Author: Velten Horn Clear advanced filters
  • Ubiquitination of histone H2A can occur on distinct lysine residues, but how each site is recognised by the specific E3 ligase remains poorly understood. Here the authors demonstrate that the E3 ligase RNF168 binds the acidic patch on the nucleosome surface, directing the E2 to the target lysine K13/K15.

    • Velten Horn
    • Michael Uckelmann
    • Hugo van Ingen
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12
  • Pertussis toxin is used extensively for perturbing Gαi/o pathways in the study of physiology and disease, but an equivalent inhibitor of Gαq signalling is not currently available to the research community. Here the authors characterize FR900359 as a specific Gq inhibitor and demonstrate its utility to dissect GPCR signalling and its potential to inhibit melanoma cells.

    • Ramona Schrage
    • Anna-Lena Schmitz
    • Evi Kostenis
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-17