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Structural basis for potent neutralization of SARS-CoV-2 and role of antibody affinity maturation

Currently there is neither a vaccine nor an effective treatment strategy available for COVID19. Here, Hurlburt et al. provide the crystal structure of a patient-derived monoclonal antibody neutralizing SARS-CoV-2 via shedding of the S1 subunit and competing for the receptor binding domain.

Nicholas K. Hurlburt
Emilie Seydoux
Marie Pancera
ResearchOpen Access27 Oct 2020
Nature Communications

Volume: 11, P: 1-7
Author Correction: Systems vaccinology of the BNT162b2 mRNA vaccine in humans

Prabhu S. Arunachalam
Madeleine K. D. Scott
Bali Pulendran
Amendments and Corrections24 May 2023
Nature

Volume: 618, P: E18
SARS-CoV-2 RBD trimer protein adjuvanted with Alum-3M-052 protects from SARS-CoV-2 infection and immune pathology in the lung

Efficient vaccines for SARS-CoV-2 are needed. Here, the authors show that a trimeric form of the receptor-binding domain of SARS-CoV-2 spike adjuvanted with alum-3M-052 protects non-human primates from disease and inhibits infection.

Nanda Kishore Routhu
Narayanaiah Cheedarla
Rama Rao Amara
ResearchOpen Access11 Jun 2021
Nature Communications

Volume: 12, P: 1-15
SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters

A collaborative study demonstrates that, compared with previous SARS-CoV-2 variants, B.1.1.529 isolates cause less infection and disease in mice and hamsters, in agreement with preliminary data from studies in humans.

Peter J. Halfmann
Shun Iida
Yoshihiro Kawaoka
ResearchOpen Access21 Jan 2022
Nature

Volume: 603, P: 687-692
Systems vaccinology of the BNT162b2 mRNA vaccine in humans

Profiling the immune responses of 56 volunteers vaccinated with BNT162b2 reveals how this mRNA vaccine primes the innate immune system to mount a potent response to SARS-CoV-2 after booster immunization.

Prabhu S. Arunachalam
Madeleine K. D. Scott
Bali Pulendran
Research12 Jul 2021
Nature

Volume: 596, P: 410-416
Adjuvanting a subunit COVID-19 vaccine to induce protective immunity

Trials in rhesus macaques show that a subunit vaccine against SARS-CoV-2, comprising the spike protein receptor-binding domain displayed on a nanoparticle protein scaffold, produces a robust protective response against the virus.

Prabhu S. Arunachalam
Alexandra C. Walls
Bali Pulendran
Research19 Apr 2021
Nature

Volume: 594, P: 253-258
Defining the risk of SARS-CoV-2 variants on immune protection

The SARS-CoV-2 Assessment of Viral Evolution (SAVE) programme provides a real-time risk assessment of SARS-CoV-2 variants with the potential to affect transmission, virulence and resistance to infection- and vaccine-induced immunity.

Marciela M. DeGrace
Elodie Ghedin
Mehul S. Suthar
Reviews31 Mar 2022
Nature

Volume: 605, P: 640-652

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Structural basis for potent neutralization of SARS-CoV-2 and role of antibody affinity maturation

Author Correction: Systems vaccinology of the BNT162b2 mRNA vaccine in humans

SARS-CoV-2 RBD trimer protein adjuvanted with Alum-3M-052 protects from SARS-CoV-2 infection and immune pathology in the lung

SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters

Systems vaccinology of the BNT162b2 mRNA vaccine in humans

Adjuvanting a subunit COVID-19 vaccine to induce protective immunity

Defining the risk of SARS-CoV-2 variants on immune protection

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