RNA translation is a core cell process that is deregulated in cancer. Here, the authors show that a machine learning approach, RiboTIE, can reconstruct RNA translation in cancer and non-cancer cells. In medulloblastoma, a brain cancer, RiboTIE enables discovery of subtype-specific microproteins.
- Jim Clauwaert
- Zahra McVey
- John R. Prensner