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Showing 1–3 of 3 results
Advanced filters: Author: Vera Magg Clear advanced filters

  • Here the authors compare genetic testing strategies in rare movement disorders, improve diagnostic yield with genome analysis, and establish CD99L2 as an X-linked spastic ataxia gene, showing that CD99L2–CAPN1 signaling disruption likely drives neurodegeneration.

    • Benita Menden
    • Rana D. Incebacak Eltemur
    • Tobias B. Haack
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-21

  • In this article the authors demonstrate that monomeric C reactive protein (mCRP) increases NOS2, COX2, MMP13, VCAM1, IL-6, IL-8, and LCN2 expression in chondrocytes. mCRP exerts a sustained catabolic effect on chondrocytes, increasing the expression of inflammatory mediators and proteolytic enzymes, which can promote cartilage extracellular matrix breakdown and osteoarthritis development and progression.

    • Clara Ruiz-Fernández
    • María Gonzalez-Rodríguez
    • Oreste Gualillo
    Research
    Laboratory Investigation
    Volume: 101, P: 1550-1560