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Showing 1–5 of 5 results
Advanced filters: Author: Vera Ruda Clear advanced filters

  • Understanding the tumor microenviroment is important before it can be exploited therapeutically. Here, the authors use single cell sequencing to study stromal cells in mouse tumors and identify a subset of interferon-licensed cancer associated fibroblasts that appear after anti-TGFβ treatment.

    • Angelo L. Grauel
    • Beverly Nguyen
    • Viviana Cremasco
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-17

  • A non-coding polymorphism at a locus associated with myocardial infarction in humans creates a CCAAT/enhancer binding protein transcription factor binding site and alters the hepatic expression of the SORT1 gene. These authors show that modulating Sort1 levels in mouse liver alters levels of plasma low-density lipoprotein cholesterol and very low-density lipoprotein, potentially explaining why polymorphisms at this locus are associated with heart disease.

    • Kiran Musunuru
    • Alanna Strong
    • Daniel J. Rader
    Research
    Nature
    Volume: 466, P: 714-719

  • The small GTPase Rab5 has been proposed to be a master regulator of endosome biogenesis; using in vivo RNA interference and mathematical modelling it is shown here that the endolysosomal system is resilient to loss of Rab5 until its concentration drops below a critical level, at which point endosomes are lost, leading to increased serum low-density lipoprotein levels, alterations in metabolism and hepatocellular polarity.

    • Anja Zeigerer
    • Jerome Gilleron
    • Marino Zerial
    Research
    Nature
    Volume: 485, P: 465-470