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Showing 1–4 of 4 results
Advanced filters: Author: Verena Apfel Clear advanced filters

  • Lineage-restricted transcription factor PAX8 is oncogenic in ovarian cancer cells. Here the authors show that PAX8 interacts and recruits a splice variant of the MECOM locus PRDM3 to control the gene expression module involved in adhesion and extracellular matrix, and consequently promotes ovarian tumorigenesis.

    • Melusine Bleu
    • Fanny Mermet-Meillon
    • Giorgio Giacomo Galli
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Transcription factors are critical regulators of cell identity. Here, the authors use computational and functional genomic approaches to show an oncogenic role of PAX8 in renal cancer. Mechanistic dissection of PAX8 functions reveal its role in activating genes associated with metabolic pathways.

    • Melusine Bleu
    • Swann Gaulis
    • Giorgio G. Galli
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10

  • Systematic metabolite profiling across cancer cell lines uncovers patterns associated with genetic and epigenetic features and reveals dysregulated metabolic states that can be exploited for anticancer therapy

    • Haoxin Li
    • Shaoyang Ning
    • William R. Sellers
    Research
    Nature Medicine
    Volume: 25, P: 850-860