Greg Barsh and colleagues show that two loci for dark skin in mice result from mutations in Rps19 and Rps20, encoding the ribosomal proteins S19 and S20. They further show that the dark skin phenotype and other pleiotropic effects of these mutations, including reduced erythrocyte count and body size, are mediated through stabilization of p53.
- Kelly A McGowan
- Jun Z Li
- Gregory S Barsh
