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Showing 1–3 of 3 results
Advanced filters: Author: Veronica Larcher Clear advanced filters

  • How and whether histone modifications regulate distinct gene networks remains insufficiently understood. Here Cattaneo et al show that DOT1L catalyzed H3K79me2 regulates fetal chamber-specific gene expression and neonatal cardiomyocyte cell cycle withdrawal to coordinate heart development.

    • Paola Cattaneo
    • Michael G. B. Hayes
    • Sylvia M. Evans
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-19

  • Mutation of LMNA, encoding Lamin A/C nuclear proteins, cause dilated cardiomyopathy and conduction disorders. Here, the authors show that patient-specific iPSC-derived CMs carrying the K219T LMNA mutation have downregulated Nav1.5 channels due to dynamic cooperation of Lamin A/C and Polycomb repressor complex 2 at the SCN5A promoter.

    • Nicolò Salvarani
    • Silvia Crasto
    • Elisa Di Pasquale
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16

  • 5-hydroxymethylation of cysteine (5-hmC) plays a role in epigenetic regulation. Here the authors analyse the hydroxymethylome in embryonic, neonatal, adult and hypertrophic mouse cardiomyocytes and show that the dynamic modulation of hydroxymethylated DNA is important for cardiomyocyte gene expression programming in heart development and failure.

    • Carolina M. Greco
    • Paolo Kunderfranco
    • Gianluigi Condorelli
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-15