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Showing 1–2 of 2 results
Advanced filters: Author: Veronick Benoy Clear advanced filters

  • The lysosomal polyamine transporter ATP13A2 controls the cellular polyamine content, and impaired lysosomal polyamine export represents a lysosome-dependent cell death pathway that may be implicated in ATP13A2-associated neurodegeneration.

    • Sarah van Veen
    • Shaun Martin
    • Peter Vangheluwe
    Research
    Nature
    Volume: 578, P: 419-424

  • Amyotrophic lateral sclerosis (ALS) leads to selective loss of motor neurons. Using motor neurons derived from induced pluripotent stem cells from patients with ALS and FUS mutations, the authors demonstrate that axonal transport deficits that are observed in these cells can be rescued by HDAC6 inhibition.

    • Wenting Guo
    • Maximilian Naujock
    • Ludo Van Den Bosch
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-15