Korn and colleagues report that Sirpα+ dendritic cells trans-present the cytokine IL-6 to T cells through a process that requires its receptor IL-6Rα bound to dendritic cells and that trans-presentation is needed to generate pathogenic cells of the TH17 subset of helper T cells in vivo.
- Sylvia Heink
- Nir Yogev
- Thomas Korn
