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Transplantation of human neural progenitor cells secreting GDNF into the spinal cord of patients with ALS: a phase 1/2a trial

A phase 1/2a study shows that human neural progenitor cells modified to release the growth factor GDNF are safely transplanted into the spinal cord of patients with ALS, with cell survival and GDNF production for over 3 years.

Robert H. Baloh
J. Patrick Johnson
Clive N. Svendsen
ResearchOpen Access05 Sept 2022
Nature Medicine

Volume: 28, P: 1813-1822

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Transplantation of human neural progenitor cells secreting GDNF into the spinal cord of patients with ALS: a phase 1/2a trial

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