The metal transporter SLC39A8 is linked to blood manganese (Mn) levels and inflammatory bowel diseases (IBD). Here, the authors show that loss of SLC39A8 impairs intestinal Mn absorption and epithelial integrity, suggesting potential therapeutic strategies targeting alkaline ceramidase 1 for IBD patients with SLC39A8 deficiency.
- Eun-Kyung Choi
- Thekkelnaycke M. Rajendiran
- Young Ah Seo
