Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–4 of 4 results
Advanced filters: Author: Vicky L Brandt Clear advanced filters
  • In the process of generating antibody diversity, DNA in the V(D)J locus undergoes programmed double-strand breaks that are made by the Rag1–Rag 2 complex. These breaks are repaired by the non-homologous end-joining (NHEJ) pathway. Cells deficient in NHEJ factors show very low levels of recombinants, so it was believed there might be another repair pathway. But this paper shows that an alternative NHEJ pathway exists, and that it functions at low levels even in wild-type cells.

    • Barbara Corneo
    • Rebecca L. Wendland
    • David B. Roth
    Research
    Nature
    Volume: 449, P: 483-486
  • Antigen receptor genes are assembled by a sequence of lineage-specific recombinatorial events, in which DNA breaks must be properly repaired to ensure cell survival and further developmental maturation. B lymphocytes, it seems, use multiple unique pathways to repair their DNA.

    • Jennifer E Posey
    • Vicky L Brandt
    • David B Roth
    News & Views
    Nature Immunology
    Volume: 5, P: 476-477
  • Organisms such as yeast and humans are capable of both nonhomologous end joining (NHEJ) and homologous recombination (HR), but bacteria have typically been assumed to be capable only of HR. A recent study shows that mycobacteria accomplish NHEJ using just two proteins (homologs of the eukaryotic Ku and DNA ligase IV), whereas eukaryotes require many factors.

    • Geoffrey R Weller
    • Vicky L Brandt
    • David B Roth
    News & Views
    Nature Structural & Molecular Biology
    Volume: 11, P: 1158-1159