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Showing 1–3 of 3 results
Advanced filters: Author: Victor A Tron Clear advanced filters

  • Vaccination in glioblastomas does lead to the emergence of tumour-antigen-specific T cells but T cell dysfunction, poor tumour infiltration and persistence hinder efficient tumour killing. Here authors identify a T cell receptor in a vaccinated glioblastoma patient that specifically recognizes the glioblastoma stem cell antigen PTPRZ1 and utilise it in T cell receptor-engineered T (TCR-T) cell therapy, resulting in efficient tumour cell killing in vitro and in a mouse model.

    • Yu-Chan Chih
    • Amelie C. Dietsch
    • Lukas Bunse
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Polyubiquitination of the tumor suppressor p53 (encoded by TP53) regulates its stability by targeting it for degradation. Wu et al. now report that UBE4B, an E3 and E4 ligase, is a key enzyme in this process and that overexpression of UBE4B in some brain tumors is associated with reduced p53 abundance, suggesting a previously unknown mechanism blocking p53 function in cancer.

    • Hong Wu
    • Scott L Pomeroy
    • Roger P Leng
    Research
    Nature Medicine
    Volume: 17, P: 347-355