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Showing 1–4 of 4 results

Advanced filters: Author: Victor A. Zammit Clear advanced filters

Geriatric muscle stem cells switch reversible quiescence into senescence

This study shows that ageing satellite cells undergo an irreversible transition from a quiescent to a pre-senescent state that results in the loss of muscle regeneration in sarcopenia; furthermore, increased expression of p16^INK4a is identified as a common feature of senescent satellite cells.

Pedro Sousa-Victor
Susana Gutarra
Pura Muñoz-Cánoves
Research12 Feb 2014
Nature

Volume: 506, P: 316-321
Treatment of human skeletal muscle cells with inhibitors of diacylglycerol acyltransferases 1 and 2 to explore isozyme-specific roles on lipid metabolism

Nils G. Løvsletten
Helene Vu
Arild C. Rustan
ResearchOpen Access14 Jan 2020
Scientific Reports

Volume: 10, P: 1-13
A zebrafish functional genomics model to investigate the role of human A20 variants in vivo

Daniele Cultrone
Nathan W. Zammit
Shane T. Grey
ResearchOpen Access05 Nov 2020
Scientific Reports

Volume: 10, P: 1-13
Absence of the primary cilia formation gene Talpid3 impairs muscle stem cell function

The Talpid3 gene, essential for primary cilia formation, is required for skeletal muscle stem cell (MuSC) self-renewal and loss of Talpid3 in MuSCs deregulates hedgehog and Wnt signalling pathways.

Victor Martinez-Heredia
Danielle Blackwell
Andrea Münsterberg
ResearchOpen Access04 Nov 2023
Communications Biology

Volume: 6, P: 1-12