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Communications Biology (1)

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Triggering AHR resolves TGF-β1 induced fibroblast activation and promotes AT1 cell regeneration in alveolar organoids

High-throughput screening and longitudinal scRNA-seq of a 3D alveolar organoid model reveals that reduction of TGF-β1-induced fibroblast activation and concurrent AHR activation promotes AT1 cell regeneration in a lung fibrosis model.

Andrew S. Hagan
Scott Williams
Rebekah S. Decker
ResearchOpen Access09 Jul 2025
Communications Biology

Volume: 8, P: 1-15

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Triggering AHR resolves TGF-β1 induced fibroblast activation and promotes AT1 cell regeneration in alveolar organoids

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