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Showing 1–3 of 3 results
Advanced filters: Author: Victor Mikhailov Clear advanced filters

  • Amphipols, bicelles and nanodiscs are used to study intact membrane protein complexes by mass spectrometry, with better preservation of oligomeric complexes than traditional detergent micelles.

    • Jonathan T S Hopper
    • Yvonne Ting-Chun Yu
    • Carol V Robinson
    Research
    Nature Methods
    Volume: 10, P: 1206-1208

  • Liu et al investigate the effects of divalent metal ions on catalysis and inhibition of the enzyme isocitrate dehydrogenase (IDH) and its cancer-linked variant R132H. They further identify the substrates for IDH as complexes with Mg2+ and show that allosteric inhibitors work by weakening Mg2+ binding of R132H, providing mechanistic insights into the basis for selective R132H IDH1 inhibition.

    • Shuang Liu
    • Martine I. Abboud
    • Christopher J. Schofield
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-16