Nature Search

The network-based underpinnings of persisting symptoms after concussion: a multimodal neuroimaging meta-analysis

Persisting symptoms after concussion (PSaC) present a complex neuropsychiatric challenge with limited treatment options due to inconsistent neuroimaging findings. Here the authors employ a multi-analytic approach to identify the salience network as a core dysfunction hub in PSaC, proposing specific cortical regions as potential targets for personalized neuromodulation therapies.

Adriano Mollica
Robin F. H. Cash
Sean M. Nestor
ResearchOpen Access23 Sept 2025
Nature Mental Health

Volume: 3, P: 1276-1290
De novo variants in the RNU4-2 snRNA cause a frequent neurodevelopmental syndrome

The non-coding RNA RNU4-2, which is highly expressed in the developing human brain, is identified as a syndromic neurodevelopmental disorder gene, and, using RNA sequencing, 5′ splice-site use is shown to be systematically disrupted in individuals with RNU4-2 variants.

Yuyang Chen
Ruebena Dawes
Nicola Whiffin
ResearchOpen Access11 Jul 2024
Nature

Volume: 632, P: 832-840
An equilibrium-dependent retroviral mRNA switch regulates translational recoding

The NMR structure of the murine leukaemia virus recoding translational signal is determined, giving insight into the mechanism of read-through in retroviruses.

Brian Houck-Loomis
Michael A. Durney
Victoria M. D’Souza
Research27 Nov 2011
Nature

Volume: 480, P: 561-564
MeCP2 and non-CG DNA methylation stabilize the expression of long genes that distinguish closely related neuron types

Neuron-specific DNA methylation and intragenic enhancers target the Rett syndrome protein methyl-CpG-binding protein 2 to regulate genes that delineate closely related neuron types, suggesting breakdown of fine-scale neuronal specification in developmental disorders.

J. Russell Moore
Mati T. Nemera
Harrison W. Gabel
Research12 May 2025
Nature Neuroscience

Volume: 28, P: 1185-1198
Author Correction: Exploring the structural distribution of genetic variation in SARS-CoV-2 with the COVID-3D online resource

Stephanie Portelli
Moshe Olshansky
David B. Ascher
Amendments and Corrections04 Jan 2021
Nature Genetics

Volume: 53, P: 254
A structure-based mechanism for tRNA and retroviral RNA remodelling during primer annealing

To prime reverse transcription of Moloney murine leukaemia virus, a transfer RNA molecule must bind two regions of the retroviral RNA, the primer binding site (PBS) and primer activation signal within the U5-PBS; here, the NMR structures of the U5-PBS RNA and tRNA primer are solved, with and without the retroviral nucleocapsid protein, which remodels these regions.

Sarah B. Miller
F. Zehra Yildiz
Victoria M. D’Souza
Research07 Sept 2014
Nature

Volume: 515, P: 591-595
Genomic investigations of unexplained acute hepatitis in children

An investigation using various methods reports an association between adeno-associated virus 2 and paediatric hepatitis of unknown aetiology.

Sofia Morfopoulou
Sarah Buddle
Judith Breuer
ResearchOpen Access30 Mar 2023
Nature

Volume: 617, P: 564-573
The USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling

Wnt receptors are controlled by their ubiquitin-mediated proteolysis. The authors show that the USP46 deubiquitylase complex potentiates Wnt signaling in human cells, Xenopus, and zebrafish by inhibiting cell surface LRP6 degradation.

Victoria H. Ng
Zachary Spencer
Ethan Lee
ResearchOpen Access05 Oct 2023
Nature Communications

Volume: 14, P: 1-13
Shared neutrophil and T cell dysfunction is accompanied by a distinct interferon signature during severe febrile illnesses in children

Severe febrile illnesses in children may be various in presentation and aetiology but involve immune dysfunction amenable to immunomodulation. Here, the authors identify shared neutrophil and T cell dysfunction and a distinct interferon signature in critically ill children with severe febrile illness.

Harsita Patel
Michael J. Carter
Leire Estamiana Elorieta
ResearchOpen Access19 Sept 2024
Nature Communications

Volume: 15, P: 1-16
Extending the toolbox for RNA biology with SegModTeX: a polymerase-driven method for site-specific and segmental labeling of RNA

It has been challenging to make long RNAs with site-specific modifications for NMR study. Here the authors present SegModTeX: a method for site-specific and segmental labeling of RNAs independent of their sequence or segment length, with applications for biological- and artificial NTP analogues at purity and scale sufficient for NMR.

Raphael Haslecker
Vincent V. Pham
Victoria M. D’Souza
ResearchOpen Access18 Dec 2023
Nature Communications

Volume: 14, P: 1-12
Adeno-associated virus 2 infection in children with non-A–E hepatitis

A case–control study investigating the causes of recent cases of acute hepatitis of unknown aetiology in 32 children identifies an association between adeno-associated virus infection and host genetics in disease susceptibility.

Antonia Ho
Richard Orton
Emma C. Thomson
Research30 Mar 2023
Nature

Volume: 617, P: 555-563
Rab11b-mediated integrin recycling promotes brain metastatic adaptation and outgrowth

Mechanisms governing adaptation of breast cancer to the brain metastatic microenvironment are unclear. Here, the authors use RNA-sequencing and Drosophila screening to identify Rab11b-mediated endosomal recycling as a unique mechanism for adaptation to a challenging metastatic microenvironment, which can be exploited by repurposing statins.

Erin N. Howe
Miranda D. Burnette
Siyuan Zhang
ResearchOpen Access15 Jun 2020
Nature Communications

Volume: 11, P: 1-15
Structural basis for packaging the dimeric genome of Moloney murine leukaemia virus

Victoria D'Souza
Michael F. Summers
Research30 Sept 2004
Nature

Volume: 431, P: 586-590
Marine oxygen production and open water supported an active nitrogen cycle during the Marinoan Snowball Earth

Snowball Earth glaciations were some of the most extreme climate events in Earth history, and are temporally linked to major biogeochemical changes. Here, using geochemical proxies, the authors show that during the Marinoan glaciation, there was likely open water, active oxygen production, and nitrogen cycling.

Benjamin W. Johnson
Simon W. Poulton
Colin Goldblatt
ResearchOpen Access06 Nov 2017
Nature Communications

Volume: 8, P: 1-10
Critical slowing down as a biomarker for seizure susceptibility

Critical slowing (associated with increased variance and autocorrelation) can precede critical state transitions. Here, the authors show critical slowing can be used as a marker in seizure forecasting algorithms.

Matias I. Maturana
Christian Meisel
Dean R. Freestone
ResearchOpen Access01 May 2020
Nature Communications

Volume: 11, P: 1-12
Cryo-EM and antisense targeting of the 28-kDa frameshift stimulation element from the SARS-CoV-2 RNA genome

The frameshift stimulation element (FSE) of coronaviruses is an RNA structure that is required for balanced expression of viral proteins and is thus a promising drug target. A structure of the SARS-CoV-2 FSE serves as a guide for the development of antisense oligonucleotides that impair virus replication.

Kaiming Zhang
Ivan N. Zheludev
Rhiju Das
Research23 Aug 2021
Nature Structural & Molecular Biology

Volume: 28, P: 747-754
Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells

Mucosal-associated invariant T cells recognize vitamin-B-derived ligands presented via the major-histocompatibility-complex-like molecule MR1. Rossjohn and colleagues demonstrate that these cells recognize a wide variety of ligands, some derived from common drugs, in an agonist or antagonist manner.

Andrew N Keller
Sidonia B G Eckle
Jamie Rossjohn
Research06 Feb 2017
Nature Immunology

Volume: 18, P: 402-411
An accurately preorganized IRES RNA structure enables eIF4G capture for initiation of viral translation

The solution structure of the J-K region of the EMCV IRES establishes a preorganized recognition mode for hijacking translation initiation factor 4G.

Shunsuke Imai
Parimal Kumar
Gerhard Wagner
Research15 Aug 2016
Nature Structural & Molecular Biology

Volume: 23, P: 859-864
Exploring the structural distribution of genetic variation in SARS-CoV-2 with the COVID-3D online resource

The emergence of the COVID-19 pandemic has spurred a global rush to uncover basic biological mechanisms to inform effective vaccine and drug development. Despite the novelty of the virus, global sequencing efforts have already identified genomic variation across isolates. To enable easy exploration and spatial visualization of the potential implications of SARS-CoV-2 mutations in infection, host immunity and drug development, we have developed COVID-3D (http://biosig.unimelb.edu.au/covid3d/).

Stephanie Portelli
Moshe Olshansky
David B. Ascher
Comments & Opinion09 Sept 2020
Nature Genetics

Volume: 52, P: 999-1001
How retroviruses select their genomes

Victoria D'Souza
Michael F. Summers
Reviews01 Aug 2005
Nature Reviews Microbiology

Volume: 3, P: 643-655
HIV-1 Tat interactions with cellular 7SK and viral TAR RNAs identifies dual structural mimicry

The HIV Tat protein recruits a host elongation factor from the cellular 7SK complex to the viral TAR RNA to ensure transcriptional elongation. Here, Pham et al. solve the structures of both 7SK and TAR RNAs in complex with Tat’s RNA binding domain and gain mechanistic insights into the process.

Vincent V. Pham
Carolina Salguero
Victoria M. D’Souza
ResearchOpen Access15 Oct 2018
Nature Communications

Volume: 9, P: 1-12
Prior chemotherapy does not prevent effective mobilisation by G-CSF of peripheral blood progenitor cells

E DeLuca
WP Sheridan
CG Begley
Research01 Nov 1992
British Journal of Cancer

Volume: 66, P: 893-899
Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence

Hong Xin
Jonathan Curry
Divaker Choubey
Research31 Jul 2003
Oncogene

Volume: 22, P: 4831-4840
Characterisation of the blood RNA host response underpinning severity in COVID-19 patients

Heather Jackson
Irene Rivero Calle
Calviño-Suárez Cristina
ResearchOpen Access17 Jul 2022
Scientific Reports

Volume: 12, P: 1-14
Head and neck cancer in Australia between 1982 and 2005 show increasing incidence of potentially HPV-associated oropharyngeal cancers

J S Hocking
A Stein
J M L Brotherton
ResearchOpen Access01 Feb 2011
British Journal of Cancer

Volume: 104, P: 886-891
Chemokines and HIV–1 second receptors

Confluence of two fields generates optimism in AIDS research

M. Patricia D'Souza
Victoria Harden
Comments & Opinion01 Dec 1996
Nature Medicine

Volume: 2, P: 1293-1300
Real or MADE-up: Investigating Mask-Associated Dry Eye (MADE) as an emerging syndrome

Michelle Ai Ling Teo
Eoin O’ Sullivan
Raman Malhotra
Reviews08 Jan 2024
Eye

Volume: 38, P: 1091-1096
Identification of novel loci for multiple myeloma when comparing with its precursor condition monoclonal gammopathy of unknown significance

Christopher Staffi Buradagunta
Shahram Arsang-Jang
Jing Dong
Research02 Nov 2023
Leukemia

Volume: 38, P: 383-385
36-month durability of ultrasound renal denervation for hypertension resistant to combination therapy in RADIANCE-HTN TRIO

Michael J. Bloch
Ajay J. Kirtane
Patric Kröpil
ResearchOpen Access27 Sept 2024
Hypertension Research

Volume: 47, P: 3467-3472
IgE-activated mast cells enhance TLR4-mediated antigen-specific CD4⁺ T cell responses

Binh L. Phong
Shaina J. D’Souza
James B. McLachlan
ResearchOpen Access06 May 2021
Scientific Reports

Volume: 11, P: 1-13
Global arthropod beta-diversity is spatially and temporally structured by latitude

A study on global arthropod biodiversity dynamics reveals that beta-diversity increased with latitude, distance, and time. Species replacement and richness difference patterns vary across regions, supporting global biodiversity expectations.

Mathew Seymour
Tomas Roslin
Paul D. N. Hebert
ResearchOpen Access08 May 2024
Communications Biology

Volume: 7, P: 1-11
A structure-based mechanism for displacement of the HEXIM adapter from 7SK small nuclear RNA

Here the structure of the HEXIM arginine rich motif in complex with the stemloop-1 of 7SK snRNA is determined, and insights are provided into how the HIV protein Tat overcomes the structural constraints required to displace HEXIM, an event required for the extraction of pTEFb during transcriptional elongation.

Vincent V. Pham
Michael Gao
Victoria M. D’Souza
ResearchOpen Access15 Aug 2022
Communications Biology

Volume: 5, P: 1-11
Risk of COVID-19 death in cancer patients: an analysis from Guy’s Cancer Centre and King’s College Hospital in London

Beth Russell
Charlotte L. Moss
Mieke Van Hemelrijck
ResearchOpen Access16 Aug 2021
British Journal of Cancer

Volume: 125, P: 939-947
Four consecutive yearly point-prevalence studies in Wales indicate lack of improvement in sepsis care on the wards

Maja Kopczynska
Harry Unwin
Judith E. Hall
ResearchOpen Access10 Aug 2021
Scientific Reports

Volume: 11, P: 1-12
Paranoid Schizophrenia is Characterized by Increased CB₁ Receptor Binding in the Dorsolateral Prefrontal Cortex

Victoria S Dalton
Leonora E Long
Katerina Zavitsanou
Research06 Apr 2011
Neuropsychopharmacology

Volume: 36, P: 1620-1630
Hippocampal Protein Kinase C Signaling Mediates the Short-Term Memory Impairment Induced by Delta9-Tetrahydrocannabinol

Arnau Busquets-Garcia
Maria Gomis-González
Andrés Ozaita
Research17 Aug 2017
Neuropsychopharmacology

Volume: 43, P: 1021-1031
A reference collection of patient-derived cell line and xenograft models of proneural, classical and mesenchymal glioblastoma

Brett W. Stringer
Bryan W. Day
Andrew W. Boyd
ResearchOpen Access20 Mar 2019
Scientific Reports

Volume: 9, P: 1-14
Tenascin-C blocks cell-cycle progression of anchorage-dependent fibroblasts on fibronectin through inhibition of syndecan-4

Gertraud Orend
Wentao Huang
Ruth Chiquet-Ehrismann
Research17 Jun 2003
Oncogene

Volume: 22, P: 3917-3926
Publisher Correction: A reference collection of patient-derived cell line and xenograft models of proneural, classical and mesenchymal glioblastoma

Brett W. Stringer
Bryan W. Day
Andrew W. Boyd
Amendments and CorrectionsOpen Access21 Jan 2020
Scientific Reports

Volume: 10, P: 1
Treating hypotension in the preterm infant: when and with what: a critical and systematic review

E M Dempsey
K J Barrington
Reviews26 Jul 2007
Journal of Perinatology

Volume: 27, P: 469-478
Loss of Prkar1a leads to Bcl-2 family protein induction and cachexia in mice

L Gangoda
M Doerflinger
H Puthalakath
Research11 Jul 2014
Cell Death & Differentiation

Volume: 21, P: 1815-1824

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