Nature Search

Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Silencing cortical activity during sound-localization training impairs auditory perceptual learning

Sensory circuits can adapt flexibly to changes in inputs yet the neural mechanisms related to experience dependent plasticity are not well understood. Here, the authors use optogenetic approaches in ferrets to show that suppression of auditory cortex during sound localization training can affect learning.

Victoria M. Bajo
Fernando R. Nodal
Andrew J. King
ResearchOpen Access12 Jul 2019
Nature Communications

Volume: 10, P: 1-12
Genetic diversity in terrestrial subsurface ecosystems impacted by geological degassing

Geological degassing can impact subsurface metabolism. Here, the authors describe microbial communities from a cold-water geyser are described and compared with other deep subsurface sites, finding a key role for an uncultivated archaeon.

Till L. V. Bornemann
Panagiotis S. Adam
Alexander J. Probst
ResearchOpen Access12 Jan 2022
Nature Communications

Volume: 13, P: 1-12
The descending corticocollicular pathway mediates learning-induced auditory plasticity

The authors use chromophore-targeted laser photolysis to selectively kill pyramidal neurons that project from auditory cortex to the inferior colliculus. They find that this eliminates the experience-dependent recalibration of sound localization, while leaving normal sound localization intact, implicating this pathway in learning-induced plasticity.

Victoria M Bajo
Fernando R Nodal
Andrew J King
Research27 Dec 2009
Nature Neuroscience

Volume: 13, P: 253-260
Efficient homing of T cells via afferent lymphatics requires mechanical arrest and integrin-supported chemokine guidance

Immune cells mostly enter lymph nodes (LN) from blood circulation, but whether afferent lymphatics contributes to LN entry is unclear. Here, the authors show, using a photo-convertible reporter, that T cells in afferent lymphatics frequently enter LN and become arrested in the subcapsular sinus, with chemokines and integrins further guiding their migration in the LN.

Rieke Martens
Marc Permanyer
Reinhold Förster
ResearchOpen Access28 Feb 2020
Nature Communications

Volume: 11, P: 1-16
Author Correction: International Guideline for Idiopathic Inflammatory Myopathy-Associated Cancer Screening: an International Myositis Assessment and Clinical Studies Group (IMACS) initiative

Alexander G. S. Oldroyd
Jeffrey P. Callen
Rohit Aggarwal
Amendments and Corrections28 Mar 2024
Nature Reviews Rheumatology

Volume: 20, P: 315
Measurement of the inelastic proton–proton cross-section at √s=7 TeV with the ATLAS detector

The measurement of the total cross-section of proton–proton collisions is of fundamental importance for particle physics. Here, the first measurement of the inelastic cross-section is presented for proton–proton collisions at an energy of 7 teraelectronvolts using the ATLAS detector at the Large Hadron Collider.

G. Aad
B. Abbott
L. Zwalinski
ResearchOpen Access06 Sept 2011
Nature Communications

Volume: 2, P: 1-14
Diverse Lenabasum pathway activation in dermatomyositis patients’ blood

Nilesh Kodali
DeAnna Diaz
Victoria P. Werth
ResearchOpen Access18 May 2025
Scientific Reports

Volume: 15, P: 1-14
Towards a novel clinical outcome assessment for systemic lupus erythematosus: first outcomes of an international taskforce

In this Consensus Statement, the Treatment Response Measure for Systemic Lupus Erythematosus Consortium presents the initial outcomes of a project to develop a clinical outcome assessment that can contribute to the regulatory approval process for therapeutic agents via its incorporation in end points of clinical trials in systemic lupus erythematosus.

Kathryn Connelly
Laura E. Eades
Yulia Pincus
Reviews11 Jul 2023
Nature Reviews Rheumatology

Volume: 19, P: 592-602
International Guideline for Idiopathic Inflammatory Myopathy-Associated Cancer Screening: an International Myositis Assessment and Clinical Studies Group (IMACS) initiative

In this Evidence-Based Guideline article, an international, multidisciplinary group of experts presents evidence-based consensus recommendations on screening for cancer in patients with adult-onset idiopathic inflammatory myopathy, addressing cancer risk stratification, screening modalities and screening frequency.

Alexander G. S. Oldroyd
Jeffrey P. Callen
Rohit Aggarwal
Reviews09 Nov 2023
Nature Reviews Rheumatology

Volume: 19, P: 805-817
Classification of myositis

The idiopathic inflammatory myopathies are a group of disorders that involve inflammation of skeletal muscles and extramuscular manifestations. New classification criteria capture a broad range of these disorders but should be further defined in the future to incorporate new data.

Ingrid E. Lundberg
Marianne de Visser
Victoria P. Werth
Reviews12 Apr 2018
Nature Reviews Rheumatology

Volume: 14, P: 269-278
The early local and systemic Type I interferon responses to ultraviolet B light exposure are cGAS dependent

Sladjana Skopelja-Gardner
Jie An
Keith B. Elkon
ResearchOpen Access13 May 2020
Scientific Reports

Volume: 10, P: 1-14

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