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Showing 1–4 of 4 results
Advanced filters: Author: Vidar Skaug Clear advanced filters

  • The authors report a new type of genetic alteration in lung adenocarcinoma. Fusions of KIF5B with RET kinase are found in 1–2% of lung cancer patients, segregate from other known alterations and can potentially be targeted using RET kinase inhibitors.

    • Takashi Kohno
    • Hitoshi Ichikawa
    • Tatsuhiro Shibata
    Research
    Nature Medicine
    Volume: 18, P: 375-377

  • In lung cancer, relatively few germline mutations are known to impact risk. Here the authors looked at rare variants in 39,146 individuals and find novel germline mutations associated with risk, as well as implicating ATM and a new candidate gene for lung cancer risk.

    • Xuemei Ji
    • Semanti Mukherjee
    • Christopher I. Amos
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • The chromosome 15q25.1 locus is a leading susceptibility region for lung cancer. Here, the authors interrogate three GWAS cohorts with 42,901 individuals to investigate potential pathological pathways such as gated channel activity and neuroactive ligand receptor interaction in lung cancer etiology.

    • Xuemei Ji
    • Yohan Bossé
    • Christopher I. Amos
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15

  • Christopher Amos and colleagues perform genome-wide association analysis for lung cancer using cohorts genotyped on the OncoArray and combing these with existing data. They identify 18 loci, 10 of which are new, finding heterogeneity across the different lung cancer subtypes, and explore candidate genes through eQTL analysis in lung tissue.

    • James D McKay
    • Rayjean J Hung
    • Christopher I Amos
    Research
    Nature Genetics
    Volume: 49, P: 1126-1132