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The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α

The TYK2 gene is associated with development of type 1 diabetes. Here the authors show that TYK2 regulates β-cell development, but at the same time TYK2 inhibition in the islets prevents IFNα responses and enhances their survival against CD8⁺ T-cell cytotoxicity; representing a potent therapeutic target to halt T1D progression.

Vikash Chandra
Hazem Ibrahim
Timo Otonkoski
ResearchOpen Access26 Oct 2022
Nature Communications

Volume: 13, P: 1-16
Building machines that learn and think with people

In this Perspective, the authors advance a view for the science of collaborative cognition to engineer systems that can be considered thought partners, systems built to meet our expectations and complement our limitations.

Katherine M. Collins
Ilia Sucholutsky
Thomas L. Griffiths
Reviews22 Oct 2024
Nature Human Behaviour

Volume: 8, P: 1851-1863
Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells

Pancreatic islets derived from stem cells are benchmarked against primary cells.

Diego Balboa
Tom Barsby
Timo Otonkoski
ResearchOpen Access03 Mar 2022
Nature Biotechnology

Volume: 40, P: 1042-1055
Loss of ZnT8 function protects against diabetes by enhanced insulin secretion

The rare loss-of-function allele p.Arg138* in SLC30A8 (encoding ZnT8) mediates protection against type 2 diabetes (T2D) through promoting better insulin secretion and enhanced glucose responsiveness, suggesting ZnT8 as a target for T2D treatment.

Om Prakash Dwivedi
Mikko Lehtovirta
Leif Groop
Research01 Nov 2019
Nature Genetics

Volume: 51, P: 1596-1606
Design of commercially comparable nanotherapeutic agent against human disease-causing parasite, Leishmania

Anupriya Baranwal
Adarsh Kumar Chiranjivi
Pranjal Chandra
ResearchOpen Access11 Jun 2018
Scientific Reports

Volume: 8, P: 1-10
Extracellular acidification stimulates GPR68 mediated IL-8 production in human pancreatic β cells

Vikash Chandra
Angeliki Karamitri
Raphael Scharfmann
ResearchOpen Access11 May 2016
Scientific Reports

Volume: 6, P: 1-11
Pathological effects and immune modulation in host during Tilapia Parvovirus (TiPV) outbreak in cage and wetland Tilapia farms

Basanta Kumar Das
Vikash Kumar
Souvik Dhar
ResearchOpen Access20 Nov 2024
Scientific Reports

Volume: 14, P: 1-17
Cholesterol bound Plasmodium falciparum co-chaperone ‘PFA0660w’ complexes with major virulence factor ‘PfEMP1’ via chaperone ‘PfHsp70-x’

Ankita Behl
Vikash Kumar
Prakash Chandra Mishra
ResearchOpen Access25 Feb 2019
Scientific Reports

Volume: 9, P: 1-17

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The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α

Building machines that learn and think with people

Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells

Loss of ZnT8 function protects against diabetes by enhanced insulin secretion

Design of commercially comparable nanotherapeutic agent against human disease-causing parasite, Leishmania

Extracellular acidification stimulates GPR68 mediated IL-8 production in human pancreatic β cells

Pathological effects and immune modulation in host during Tilapia Parvovirus (TiPV) outbreak in cage and wetland Tilapia farms

Cholesterol bound Plasmodium falciparum co-chaperone ‘PFA0660w’ complexes with major virulence factor ‘PfEMP1’ via chaperone ‘PfHsp70-x’

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