Giacomo Cavalli, Anne-Marie Martinez and colleagues identify a large set of genes that are bound by PRC1 in the absence of H3K27me3 in Drosophila larval tissues and in differentiated human cell lines. Many of these genes, which regulate cell proliferation, signaling and polarity, are upregulated in PRC1-mutant tissues and contribute to tumor formation in Drosophila.
- Vincent Loubiere
- Anna Delest
- Giacomo Cavalli
