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Showing 1–18 of 18 results
Advanced filters: Author: Vincent M. Rotello Clear advanced filters

  • Intracellular biothiols can degrade nanoparticle monolayers, compromising the function of these potentially promising tools. Here, we describe a label-free method for quantifying the intracellular stability of quantum dot monolayers, using laser desorption/ionization mass spectrometry coupled with inductively coupled plasma mass spectrometry.

    • Zheng-Jiang Zhu
    • Yi-Cheun Yeh
    • Vincent M. Rotello
    Research
    Nature Chemistry
    Volume: 3, P: 963-968

  • Application of supramolecular chemistry in living systems is challenging because of the inherent chemical complexity of cellular environments. Now, the use of a carefully designed host–guest system featuring diaminohexane-terminated gold nanoparticles and complementary cucurbit[7]uril macrocycles has been shown to provide triggered activation of a therapeutic system in living cells.

    • Chaekyu Kim
    • Sarit S. Agasti
    • Vincent M. Rotello
    Research
    Nature Chemistry
    Volume: 2, P: 962-966

  • Regulation of bioorthogonal catalysis in living systems is challenging because of the complex intracellular environment. Now, the activity of protein-sized bioorthogonal nanozymes has been regulated by binding a supramolecular cucurbit[7]uril ‘gate-keeper’ onto the monolayer surface. This arrangement enables the controlled activation of profluorophores and prodrugs inside living cells for imaging and therapeutic applications.

    • Gulen Yesilbag Tonga
    • Youngdo Jeong
    • Vincent M. Rotello
    Research
    Nature Chemistry
    Volume: 7, P: 597-603

  • Protein imbalances in serum can be correlated with disease, but measurement and subsequent diagnosis is made difficult by the complex composition of serum. Now an array-based sensor, containing synthetic gold nanoparticles and biocompatible green fluorescent protein, has been developed that can detect proteins in undiluted human serum at physiologically relevant concentrations.

    • Mrinmoy De
    • Subinoy Rana
    • Vincent M. Rotello
    Research
    Nature Chemistry
    Volume: 1, P: 461-465

  • A high-throughput nanosensor based on a gold nanoparticle and fluorescent proteins allows mechanisms of chemotherapeutic drugs to be screened in minutes, offering a tool for expediting research in drug discovery and toxicology.

    • Subinoy Rana
    • Ngoc D. B. Le
    • Vincent M. Rotello
    Research
    Nature Nanotechnology
    Volume: 10, P: 65-69

  • Electric currents can be steered by coupling the flow of electrons and ions in films of gold nanoparticles coated with ionic ligands.

    • Xi Yu
    • Vincent M. Rotello
    News & Views
    Nature Nanotechnology
    Volume: 6, P: 693-694

  • DNA provides more than lock-and-key control of assembly. Careful engineering of hairpins and loops provides the means to control the kinetics of particle assembly, allowing structures to be 'glued' together by heating.

    • Vincent M. Rotello
    News & Views
    Nature Materials
    Volume: 8, P: 539-540

  • Assembling complex structures out of simple colloidal building blocks can produce materials with important practical properties and enables enhanced understanding of the self-assembly processes on several length scales. This paper shows self-assembly of a multi-component colloidal mixture of magnetic and nonmagnetic particles driven by magnetic interactions.

    • Randall M. Erb
    • Hui S. Son
    • Benjamin B. Yellen
    Research
    Nature
    Volume: 457, P: 999-1002

  • Neutrophils are the first responders in acute inflammatory events such as acute respiratory distress syndrome and tend to home to lung capillaries during acute inflammation, where they can cause tissue damage by diapedesis and secretion of specific molecules. Here the authors show that nanoparticles coated with agglutinated proteins selectively target activated neutrophils in inflamed lungs and can be used for imaging and therapeutic purposes.

    • Jacob W. Myerson
    • Priyal N. Patel
    • Jacob S. Brenner
    Research
    Nature Nanotechnology
    Volume: 17, P: 86-97

  • It is generally believed that rapid dissipation means that spatially precise heating is not feasible via thermoplasmonic means. Here, the authors induce highly localized heating around plasmonic nanostructures by pulsed laser irradiation, which effects chemical modification of surface bound molecules.

    • Calum Jack
    • Affar S. Karimullah
    • Malcolm Kadodwala
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-8

  • In this Review, Rotello and colleagues discuss the mechanisms by which nanomaterials can be used to target antibiotic-resistant bacterial infections, highlight design elements and properties of nanomaterials that can be engineered to enhance potency, and explore recent progress and remaining challenges for clinical implementation of nanomaterials as antimicrobial therapeutics.

    • Jessa Marie V. Makabenta
    • Ahmed Nabawy
    • Vincent M. Rotello
    Reviews
    Nature Reviews Microbiology
    Volume: 19, P: 23-36

  • In vitro studies using three-dimensional tumour models and mathematical simulation show that positively charged particles are better for delivering therapeutics to viable cells, whereas negative particles are better when deep tissue penetration is required.

    • Byoungjin Kim
    • Gang Han
    • Neil S. Forbes
    Research
    Nature Nanotechnology
    Volume: 5, P: 465-472

  • Nanotechnology is having a major impact on medicine and the treatment of disease, notably in imaging and targeted drug delivery. It may, however, be possible to go even further and design 'pseudo-cell' nanofactories that work with molecules already in the body to fight disease.

    • Philip R. LeDuc
    • Michael S. Wong
    • Minami Yoda
    Comments & Opinion
    Nature Nanotechnology
    Volume: 2, P: 3-7